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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78e0e782fb871ef7ecfb5e8482b7c0b47200275234472bc82365d7d3f98b3c8b' 
  AND token = 'nEoQpZQIDB0LUX7q1PYzu8BKn3Zkr06PuBkx+WINA10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}