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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4eff6d002b992b56b226196eb27d9c27b9dc80528228343b055bfc8b43940da' 
  AND token = 'TFhGnLdQe5LUsAi1RI621IHY8grbSaMCWM0buOVUEBs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}