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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '019ea78d9605d88624779bfe4d6f05edd7e8e0fc2e8110d070f272377067d209' 
  AND token = '8xRCNCY7EiwlWrtZpXKUC06OMNmr0K0uAsKa+zaadxc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}