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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b8b7ad3c7148888ff58da203e76f1e5ea51ab8a9adca3807acce5576b4f662' 
  AND token = '8/LXoeb3qXWW0edlREbAD+F4MUFxrCn44mkCKcFA2g8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}