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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c2b273b21ca68a017044cb5c7daf2e7ee237f0934a1a6a93909c152281ac001' 
  AND token = '8x4m60kV3V4Qt9Iwuc+skrAjUIUdmTXIhMlG52DH/Qw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}