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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01a487fe576e8225165c7cc535c40025f0c93b7dd2af627b53ab633f5e28c601' 
  AND token = 'DNosXYBJ9prTge4HS0tWCcU3IAvXsNHg+FoNVCHq6lM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}