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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10f44317396ed191e35aee5d6aebbd397371a4f41f88a91c1d6e518a6418ce53' 
  AND token = 'xbJ3FZIt/fIqwMgWDuiNhjgR1FfeQOhdyxi32cnqHTg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}