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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b816e8a97915cef9644026514111c0112a36c53f3d4c4822f99b261a6c3d40c' 
  AND token = 'fQMALKhz+f4+YzVJGfQkuEdde5G9dEDdVmZRdMmxxLk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}