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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a6d9b3a28424244a0929a74ab560f7761dd88aa98f3fb9d978e51204434a704' 
  AND token = 'LqHxz/w7dHZ0CuiI2jky2xJH3XV8ytPDuOApNA7kxzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}