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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21a4a1e89c1ea7e2d0b272f9ee3916a36dba5d173a829f318a032f638aba928e' 
  AND token = 'OFN7hTWsaWsGGNUJk5pNGFIrHsUoSmB0TTse8aRy8Nc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}