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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e6647f589d3fb995483986ef4c1fee97242d3ef4e8c6820f1f7fbbd1d800088c' 
  AND token = 'm/pLN1NaFwpwLf0kUTNnLmqE8r3xt6aCzTmtKp7kSGY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}