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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b65adba53405f5c50a7f6a108a4957b552c2f2a932a393bddfd79439a2adf378' 
  AND token = 'FsyCyYJO4u6lcnHT5JDHaXYeeMPQKUkbW5bWjvE7mwg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}