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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '243df86e7b4f44678ae745e70e9953e31b4ca4dcd390a4234b8dc4d8f4103300' 
  AND token = 'E9zxbC2xKaMnY+l4rkXkM6uOVDvYWdVPh75/WU0NdLw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}