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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74ca807de40a95217f60e0c38494369820d42f72278059c1a2fdddb27459ca20' 
  AND token = 'ohpnLxlgnnSOAmVTVfJ/lK3mKOPxMJ2mI5plu65zdTo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}