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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '645c7fd8da7734c35a08264015b9bfa1fd730d37ffad8aafb63fe02ded0d5336' 
  AND token = 'Pz/b8CADYxf3jnwyTS0zZMuZyxol1Wy2pG5LSfaSHxk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}