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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9e5000a7f4bc944b788fd1a745ef79d21ee309b738030f60685ed63a2da6f4ce' 
  AND token = 'DZ/rf8oQAjxDjwwY51CyNVTqCtvRsvTH1GQ7ssB5fFc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}