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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '888a4f2af8141ca4914f21f0eb723069e21a0bbf597249aa30a8b1ead43e76f0' 
  AND token = 'xoYyg3UVQP4D3Oorj4mz3DYWB3MQqS3HFEi39OSNu+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}