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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78f41d97ae5461e157e16dc34c0372db1c8c9daaac02f9a54ff437c725e89db7' 
  AND token = '8E2cvi+AVYbw9MWiKw04UE/WIAA68nmiW73sa+rMdj0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}