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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8363800a80054a08a6d691eeb4c50d72fd942e578977292be546d9d2d2ee6a29' 
  AND token = 'fvm+Vq19ZxV+2kK5jnNeZGyBqAfco/PkN9PU86VsF3A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}