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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ca0f77badb6dfccd27aead6ff2035bc3aa0df643359b25daef2fb11f1b2fb70' 
  AND token = 'O3wCZa8vRHhMQo8MRMgWVWDq2Vt7Nk0FQIk3Im5ZlUo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}