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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c605b1784afcddbc47d6606aceeca4c9461fa6e2f4cdd5704987c16781275e3b' 
  AND token = 'bdotZtKD3Ad/IuM5I5UahMtBfXrkiJ+zcGXTtEVsSK0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}