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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '163ae06810bef0cd1c430e1cb92917c4d5aab63a96e2c8d5066628eb3d5d6621' 
  AND token = 'D0zE8J9Y4ZN5qWJdDm4TYCEq7depml90uJZ0NtPebUw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}