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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf8e6b4d04021f7c179848d039c0d4b49e6530f42ff417715da5cd2f5097d3b1' 
  AND token = 'TsE3RFEVwczu9+XmK9oFcAkug33FaKC8lAZcsD8Ph7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}