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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b49fb6ddbbe6ece4b3b30a894d938ae33e8be9e79889138dd521e04f04b0bdd6' 
  AND token = 'pWSMi4Y/RATnF2Rmz/JoMcmF8DWDAd8MspiiiNECE+c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}