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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '144eed066e800d2e47ec23307810b3a170147d94fc5cb9795ac632268b9b04f6' 
  AND token = 'EKLf74ziTOnl+IXiBYCW38+bx68hMv8p614xistAWfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}