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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '365e93b113e91f9d606351cdc2a9e0400aa969f26071b48f27305285d4f09166' 
  AND token = 'IGuRAdqbbdXsJSkGEG31iZNsHYhtkgWHU0iXbi2HtDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}