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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81d9128e567d4a8c2ea01ebaee6ca059c5962e8375357795bada4a13c361aada' 
  AND token = 'fRJRI+UZU53wsHodY9P+vLf1aTq8NtMXXioGpAyntA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}