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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9e41cf44e5433aaaf4c921fe4e07a75465f1d17326603976f3a71a03b8b44408' 
  AND token = 'o/REKEG4UiBGQIrddw/e3ZhVZn7KYWVYF67kD778DVg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}