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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a6b5b34a1740dfbd465ff8db557554be2a64964741003529b2d6f0eb45c6fdaa' 
  AND token = 'fFvmM5Gs6PcVC9vOptk/cXrhkAZBtf8T14xMtXnUL4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}