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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e325f463d27b91cb15824c56b6b12178a9da77c6dda3abcb8d9b87cc02057248' 
  AND token = 'lSmOUkmRs4nDD1/xZCkoe1SMmgYBtki+TyfNrAaCtNQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}