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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a250a359e5394a12764ae9191dd18d93041eef6711b60296be415983f6f4044' 
  AND token = '2zDTSkAM+prJP7wjiP/bImJBsPN4G5N1yLmFTf1Xwxs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}