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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0365d9c241792a02678d4a20655fc2ac09e2357dfcabbb09dbf2e6b075e88b76' 
  AND token = 'a0HNkEOwZhQ6uvikbdOQG4slCeMca38cYjzhsgeP5Bs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}