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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c4930375b4009683a8a8f47a72fd0324b10a5cd1530ac778d5d537de78a829' 
  AND token = 'TYUM4bJ2VtP1Vzu0L2AYHfp+gm+IF0kTSk9UE7pFZAo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}