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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da66a0edb3a3f2ea9356ac1588d0a0fff116f1a0fe284f9b78b5f5b7648b4551' 
  AND token = 'JUU7P5ztpyfIiPzBCqCV0xIxCCeye6r3iLHdKEPM3yk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}