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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8c21d4a6c747a02b14c813504884add3e41066ed9107dacaf3939f161832601' 
  AND token = 'tVz0IF11ZurnW6nqodVyEIY49uyTBVEY/cPBQokMC+8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}