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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '243c7e3cd01b8f06c61e984b6d7f716f16e5aedbd11ca84104c01e80dab7d9f1' 
  AND token = 'CILM7Gzpmmjx2/A/DSnFPLCG2vlfW3TFnvMDTJcppqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}