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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '353f7dc93cb08d642b3b4a95a343b1bfe93095c0721f6411b39ada579c14e427' 
  AND token = 'V4wBYZ3s1GBQbHBE/6HR36CRItbX9b/eGJ3qgyeTvDE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}