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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '61e9e165eb6d2b371e72103d5f45d07271a3c017e50ce29a4b5203430c4e175a' 
  AND token = 'vRA/lOiSzgyQ0Qy4WPTnX/OgUs4r+ABxc7Su8RA93d0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}