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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c581934fde348e3799b537c9997e3b5301ea35aa469dfb2e6b55abd6ca406442' 
  AND token = 'D+x+EA/OzwbcNueOPugdBFOpWjFz0xNTizk0q73FmYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}