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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6dc807104e5a1eb8a57a1a6a3bef9f0056e2c5a201f1dc4b6d8a342c85780710' 
  AND token = 'YdtsIMFxgmzcQgZBpBogH8hY4t/HUVNpgPWPZfaTaTE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}