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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '225f85c188c1d31dd438851112bbfceb49587f6554a7662e4b2198884c1755d9' 
  AND token = 'tNKoi2UlSysS9s/lIwdDGOi91rPxRRnCFSBkaPso6fU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}