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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d0c0a827feb6e86972cd0b56ac54fb3c3cd65d0b2e4000bfc1877e105352a8a' 
  AND token = 'xxIqz4TJsL/wHipnp22cKeOShD+rhn7OpoKwg31Xp00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}