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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27c6c86530556990af844a68891d2945351418daf552e4b64423ed1143f31d0a' 
  AND token = '280HWzV94Ng/fDIro21DMUcjSW8HlOAqg+B2iyvKTao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}