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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8b5cf774edfb8f22de67e6da102e1a8c8b49ca9787300fa6d4462139ecff803' 
  AND token = 'Hvm2mZf+dDH1fUFC8lAOc2vIGqZX8RZVORJmUBZBerg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}