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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1295ba8554b711a8a2b58417644547f0f0a85303c4daf268c7c7646c2f8ed1e8' 
  AND token = 'IGACoekFFdndUorOTO043RwBt9b2pWWy+ret/G4xoE4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}