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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6293b7cd5e323572b9d8fa79acf69120f80a35cc3b601d0d5836dd9cb8e3fade' 
  AND token = '4P4zuU5LgrUtV1EpKpXRfGNxRvN81ON3BfsyWcqrCig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}