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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25c074ab676bafe21cd7efc0a381def2eb7d98daeac5e497974345a36ce9fdec' 
  AND token = 'iYIsrOP9+NFQ8mwWz6cV0QV+v3AW91jBUnDvYK8cVyA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}