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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ee37299e9812fe3f74bc3a7e49f0884a993a06e1319033a80fe5da3080f0f409' 
  AND token = 'ICL6nBALB7KjknMMgpwBflOTM8t7xVMeVcr7XvJbaSk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}