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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21cf9249275b5cf013912d8d1806b8e6ed91a09a592f719dc61932f82aa6afac' 
  AND token = '2HX0AH+Xy6XadRvV2TS7fTBpOcpTVhFqzKkFEEQtkIw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}