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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '370caa4c52201d3ce112e7eeb22b3d0d3cc23ca28f9730f79f5e24c81244b51b' 
  AND token = 'oXQ5yY7CRfKuqPvhccKVwUEifZKpVs4XRDfJVSmkCwI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}